Hemorrheologic effects of pyrimido-pyrimidine derivatives
Ambrus, J.L.; Stadler, I.; Kulaylat, M.; Koreshi, A.; Akhtar, S.
Journal of Medicine 27(1-2): 21-32
1996
ISSN/ISBN: 0025-7850 PMID: 8863175 Document Number: 462206
A series of pyrimido-pyrimidine derivatives were tested for their effect on membrane fluidity-deformability of human red blood cells and on human platelet aggregation. These agents were also tested for their intracellular cAMP increasing activity and proliferation inhibitory activity in neoplastic cells. The order of activity was established and clinical implications discussed. Several derivatives are under study as antineoplastic agents.
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