Effect of nimodipine on infectious brain edema in rabbits
Wen, F.Q.; Zhang, B.L.; Yu, P.L.; Tao, Y.G.
Zhongguo Yao Li Xue Bao 17(3): 212-214
1996
ISSN/ISBN: 0253-9756 PMID: 9812737 Document Number: 459950
AIM: To study the effect of nimodipine (Nim) on infectious brain edema (BE). METHODS: An infectious BE model was induced by injection of Bordetella pertussis suspension (BPS) into right internal carotid artery in rabbits. Eighteen rabbits were randomly divided into 3 groups ( n = 6 ). Group BE: BPS (0.6 mL cntdot kg-1) was given; group NS: normal saline was given as control; group Nim: 10 min after injection of BPS, Nim, 10 mu-g cntdot kg-1, was injected iv as a bolus followed by continuous infusion of 0.75 mu-g cntdot kg-1 cntdot min-1. All the rabbits were kept under observation for 4 h. Evans blue staining was assessed; water, calcium, calmodulin (Cal), and sodium contents were determined in the right brain. RESULTS: Nim vs BE: water 82.2+-1.0% vs 84.4+-1.2 (P lt 0.01); calcium 10.5 +- 1.3 mmol cntdot kg-1 dry tissue vs 17.5 +- 1.4 (P lt 0.01); Cal 15.9 +- 1.8 mu-mol cntdot kg-1 wet tissue vs 24.0 +- 3.0 ( P lt 0.01); sodium 173 +- 7 mmol cntdot kg-1 dry tissue vs 275 +- 38 ( P lt 0.05). No significant difference for Evans blue staining between the two groups. CONCLUSION: Nim had beneficial effect on the infectious BE.