Effects of nimodipine and ofloxacin on staphylococcal brain abscesses in rats
Ceviz, A.; Inalöz, S.S.; Ciçek, R.; Sari, I.; Gül, K.; Sanli, A.
Arzneimittel-Forschung 47(12): 1402-1405
1997
ISSN/ISBN: 0004-4172 PMID: 9450172 Document Number: 483591
The therapeutic effects of nimodipine (CAS 66085-59-4) and ofloxacin (CAS 82419-36-1) were investigated against experimental brain abscess formation in rats. Nimodipine, a 1,4-dihydropyridine derivative, is chemically related to nifedipine but the smooth muscle relaxant effect preferentially acts on cerebral arteries. Ofloxacin is a member of 4-Quinolone broad spectrum antibiotics. Ninety-six male Sprague-Dawley rats were inoculated intracortically with Staphylococcus aureus and then different groups were treated with either saline, ofloxacin or the combination of ofloxacin and nimodipine. The rate of brain abscess formation and mortality were considerably decreased by nimodipine and ofloxacin therapy. Combination therapy was found histologically to be considerably more effective than ofloxacin alone against brain abscess formation in rats.