Mitogenic effects of staphylococcal antigenic substances on irradiated lymphocytes from Wistar rats
Kholodna, L.S.; Holeva, O.H.; Liubchenko, T.A.; Kucherenko, M.I.
Ukrains'kyi Biokhimichnyi Zhurnal 71(5): 65-68
1999
ISSN/ISBN: 0372-3909 PMID: 10726312 Document Number: 500668
Proliferation activity of lymphocytes from rats was studied using a micromethod of blasttransformation reaction after X-ray irradiation (absorbed doses for animals were 0.5 and 1 Gy). Staphylococcus protein A and peptidoglycan stimulated the proliferation of irradiated lymphocytes. It was assumed that staphylococcus antigen substances held radiation protective effects. Staphylococcus protein A may be used for stabilization of lymphopoesis and functional activity of humoral and cellular immunity in irradiated animals due to T- and B-mitogenic properties.