Effect of 17beta-estradiol on haloperidol effects in Wistar rats
Andreeva, I.A.; Kudrin, V.S.; Raevskiĭ, K.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 65(6): 10-13
2002
ISSN/ISBN: 0869-2092 PMID: 12596525 Document Number: 542725
It is established that the haloperidol catalepsy is much less pronounced in Wistar females than in males. Estradiol (10 mg/kg, i.p.) decreased intensity of the haloperidol catalepsy, reduced the haloperidol-induced increase in the dopamine turnover, and decreased the level of dopamine metabolites in nucleus accumbens of both female and male test animals. However, these effects are also more pronounced in females.
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