Effects of lesions of monoaminergic system in the brain on the hypotensive effects of clonidine in rats
Szreniawski, Z.; Kostowski, W.; Widy-Tyszkiewicz, E.
Polish Journal of Pharmacology and Pharmacy 28(6): 605-608
1976
ISSN/ISBN: 0301-0244 PMID: 1012984 Document Number: 98301
Bilateral lesions of the locus coeruleus markedly reduced hypotensive effects of clonidine in rats. Lesions shifted laterally did not evoke any significant change of the hypotensive effects of clonidine or bradycardia induced by it. Lesions of the ventral and dorsal noradrenergic tract at the midbrain level and lesions of the midbrain raphe area failed to change hypotensive response to clonidine.