Interaction between the cardiovascular effects of clonidine and the kappa-opioid agonist U-50,488H in the anterior hypothalamic area of the rat brain
Verberne, A.J.; Louis, W.J.
Journal of Pharmacy and Pharmacology 41(2): 131-133
1989
ISSN/ISBN: 0022-3573 PMID: 2568424 Document Number: 333026
In thiobutabarbitone-anaesthetized rats, microinjection of clonidine (1-40 nmol) into the anterior hypothalamic area (AHy) produced dose-dependent reductions in mean arterial blood pressure and heart rate. Microinjection of the .kappa.-opioid agonist U-50,488H (3 and 10 nmol) did not modify these parameters. Simultaneous co-administration of clonidine (4 nmol) and U-50,488H (10 nmol) into the AHy resulted in significant potentiation ofthe clonidine-induced hypotension and marked attenuation of the bradycardia. A lower dose of U-50,488H (3 nmol) co-administered with clonidine (4 nmol) did not influence the cardiovascular respnses to clonidine. These findings suggest that AHy neurons involved in the cardiovascular responses to clonidine may be modulated by .kappa.-opioid receptor sitmulation.