Effects of clonidine on experimental stomach ulcer in rats
Luo, G.Y.; He, Y.; Tu, L.B.
Zhongguo Yao Li Xue Bao 11(5): 457-459
1990
ISSN/ISBN: 0253-9756 PMID: 2130604 Document Number: 356438
Clonidine 2 mg/kg ig inhibited the rat gastric ulcers induced by pyloric ligation, stress and indomethacin by 71%, 77% and 82%, respectively. Clonidine 2 mg/kg ig tended to accelerate the healing of gastric ulcer induced by acetic acid, and the healing rate was 61%. Clonidine decreased the secretion of gastric acid and pepsin, and increased the release of gastric barrier mucus. These actions may contribute to its protective effect against ulceration.
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