Inhibition of experimental stress ulcer formation in rats
Fehr, H.F.; Aebi, M.; Finger, J.; Clémençon, G.H.
Scandinavian Journal of Gastroenterology. Suppl 67: 187-189
1981
ISSN/ISBN: 0085-5928 PMID: 6941405 Document Number: 180755
We present an operation model in rats, which according to our opinion prevents duodenogastric reflux effectively. The duodenum is divided distally from the pylorus and a pyloro-jejunostomy performed combined with a Roux-en-Y anastomosis. Rats operated this way and submitted to restraint stress developed significantly less stress lesions than operated control under same conditions. However, operated rats submitted to the operation and offered a 5 mMol/l drinking solution of crude taurocholic acid during 20 days before submitted to stress had significantly more stress lesions than operated animals with tap water before restraint stress.