Effect of kininotropic preparations on ulcer formation in rats
Faermerk, I.F.; Shvarts, G.I.
Farmakologiia i Toksikologiia 51(2): 82-84
1988
ISSN/ISBN: 0014-8318 PMID: 2454203 Document Number: 318200
The effects of an inhibitor of kininogenesis trasylol, its activator, cellulose sulfate, and inhibitors of kininases, captopril and D-penicillamine, as well as an antagonist of kinins, parmidine, on the development of the rat ulcers induced by histamine, absolute ethanol, reserpine and diclofenac sodium were studied. It was found that the drugs influencing metabolism and effects of kinins (except trasylol) exert differently pronounced antiulcer effects during modelling gastric ulcers by administering ethanol, reserpine and diclofenac sodium. At the same time they were inactive on the model of histamine-induced ulcers in rats.