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The effect of a combined vitamin--antioxidants preparations on hemostasis in rats with experimental hyperperoxidation

Byshevskiĭ, A.S.; Galian, S.L.; Ral'chenko, I.V.; Rudzevich, A.I.; Alborov, R.G.; Vinokurova, E.A.; Volkov, A.I.; Umutbaeva, M.K.

Eksperimental'naia i Klinicheskaia Farmakologiia 68(3): 34-36

2005

ISSN/ISBN: 0869-2092
PMID: 16047678
Document Number: 592616
Experiments on a group of 308 rats showed that prooxidant (lead acetate) introduced per os with daily meals decreases the antioxidant potential (increases lipid peroxidation, LPO) and reduces tolerance with respect to thrombin (increases the level of intravascular blood coagulation markers). For the same treatment on the background of a vitamin - antioxidants preparations (complivit or selmevit), the level of changes was significantly decreased and the resistance to thrombin was increased. Selmevit (containing selenium) was more effective. It is concluded that complex vitamin--antioxidants preparations can be used for correcting hemostatic changes in cases of hyperoxidation.

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