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Dynamics of lipid peroxidation in blood and organs of rats after irradiation at low doses and the effect of antioxidants

Baraboĭ, V.A.; Oliĭnyk, S.A.; Blium, I.O.; Korniĭchuk, H.M.; Khmielievs'kyĭ, I.V.

Ukrainskii Biokhimicheskii Zhurnal 66(5): 39-47

1994

ISSN/ISBN: 0201-8470
PMID: 7747345
Document Number: 422619
A study was made of the dynamics of lipid peroxidation (LPO) in rats after the whole-body 1.0 Gy X-irradiation (ten fractions of 0.1 Gy at a 24-hour interval; 0.425 R/min) and the possibility of correction LPO with alpha-tocopherylacetate, ascorbic acid and catechin complex by means of a single and combined administration. The accumulation of primary and secondary LPO products in blood, radiosensitive (spleen and mucosa of small intestine) and radioresistant (brain) organs is established. The administration of mentioned antioxidants diminishes the content LPO products, but does not completely normalize the latter. Administration of antioxidant complex was most effective.

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