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Effect of vitamin E administration on photoreceptor outer segment and retinal pigment epithelium of vitamin E deficient rats

Amemiya, T.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 51(2): 114-118

1981

ISSN/ISBN: 0300-9831
PMID: 7287334
Document Number: 176556
Male Wistar rats were given a diet deficient in vitamin E from 20 days old for 6, 8.5, 12 or 18 months without or with being given 100 mg vitamin E once a week 4 times before death. In rats given the deficient diet for 12 or 18 months, the photoreceptor outer segment did not regenerate after 400 mg vitamin E was given. The retinal pigment epithelium was filled with lipofuscin granules. In rats given vitamin E after vitamin E deficiency for 6 months the photoreceptor outer segment returned to normal but some retinal epithelial cells still contained lipofuscin granules.

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