Restoration of tissue antioxidants and prevention of renal stone deposition in vitamin B6 deficient rats fed with vitamin E or methionine
Selvam, R.; Ravichandran, V.
Indian Journal of Experimental Biology 31(11): 882-887
1993
ISSN/ISBN: 0019-5189 PMID: 8112761 Document Number: 1185
Observed loss in body weight gain, increased lipid peroxidation reaction, decreased concentrations of antioxidants, ascorbic acid, alpha-tocopherol and reduced glutathione and antioxidant enzymes, glutathione peroxidase and catalase and increased concentration of hydroperoxides and hydroxyl radicals in vitamin B-6 deficient rat liver (J Nutri Biochem, 2 (1991) 245) and kidney (Biochem International, 21 (1991) 599) were nearly normalized on feeding with vitamin E or methionine. Accumulation of oxalate and calcium during vitamin B-6 deficiency was abolished by feeding vitamin E or methionine. Calcium oxalate deposition observed in vitamin B6 deficient kidney was completely prevented when fed along with vitamin E or methionine. However the hyperoxaluria and hypercalciuria persisted even after feeding with vitamin E or methionine.
Document emailed within 1 workday
