Reversal of severe hepatic veno-occlusive disease by combined plasma exchange and rt-PA treatment

Espigado, I.; Rodríguez, J.M.; Parody, R.; Carmona, M.; Digón, J.; Olloqui, E.

Bone Marrow Transplantation 16(2): 313-316

1995


ISSN/ISBN: 0268-3369
PMID: 7581155
Document Number: 1186
We report the successful treatment of a case of severe hepatic veno-occlusive disease (VOD) by combined treatment with exchange plasmapheresis and fibrinolysis with rt-PA. Very advanced alterations of hepatic vascular circulation, evaluated by Doppler sonography, reverted to normal after treatment. Severe VOD, defined by McDonald's criteria, produces a mortality of 98%. This case suggests that this new method of combined treatment might contribute to changing the usually bad prognosis of this clinical condition.

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Reversal of severe hepatic veno-occlusive disease by combined plasma exchange and rt-PA treatment