Hypotensive effects of eicosapentaenoic acid (EPA) and its influence on eicosanoid metabolism in spontaneously hypertensive rats

Lam, B.K.; Marcinkiewicz, E.; Quilley, J.; Hirai, A.; Yoshida, S.; Tamura, Y.; Wong, P.Y.; Lam, B.K; Marcinkiewicz, E; Quilley, J; Hirai, A; Yoshida, S; Tamura, Y; Wong, P.Y

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Hypotensive effects of eicosapentaenoic acid (EPA) and its influence on eicosanoid metabolism in spontaneously hypertensive rats

Lam, B.K.; Marcinkiewicz, E.; Quilley, J.; Hirai, A.; Yoshida, S.; Tamura, Y.; Wong, P.Y.

Journal of Hypertension. Suppl Official Journal of the International Society of Hypertension 4(3): S453-S455

1986

ISSN/ISBN: 0952-1178

PMID: 3023590

Document Number: 275713

Oral administration of pure eicosapentaenoic acid (EPA) ethyl ester caused a reversible hypotensive effect in spontaneously hypertensive rats. Treatment with EPA also lowered the platelet response to ADP and inhibited the conversion of leucotrienes (LTs) A4 and LTB4 and other sulphidopeptide leucotrienes. Therefore, diet supplemented with EPA may lower blood pressure in hypertensive rats and affect cardiovascular functions which may be mediated through eicosanoid metabolism.