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Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice

Lane, P.W.; Murphy, E.D.

Genetics 72(3): 451-460

1972

ISSN/ISBN: 0016-6731
PMID: 4643821
Document Number: 44634
Among mice of strain SB/Le, homozygous for the mutant beige (bg), satin (sa) and white-bellied agouti (Aw), 70% developed progressive pneumonitis by 6 mth of age. Among backcross offspring from an outcross to C57BL/6J-Aw-J, 49% of homozygous beige and 11% of non-beige genotypes developed pneumonitis by 6 mth of age. The evidence indicates that a specific action of the beige gene increases susceptibility to progressive pneumonitis. Beige mice show giant lysosomal granules in the leucocytes and pigment dilution closely analogous to the Chediak-Higashi syndrome in man and similar disorders in mink and cattle.

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