Metrazol thresholds in inbred and non-inbred audiosensitive mice
Alexander, G.J.; Kopeloff, L.M.; Alexander, R.B.
Neurotoxicology 2(1): 91-95
1981
ISSN/ISBN: 0161-813X PMID: 15622728 Document Number: 168875
Mice of the O'Grady strain which were inbred for susceptibility to audiogenic seizures were more sensitive to pentamethylenetetrazol (Metrazol) convulsions than mice of the parent Swiss-Webster strain from which they were originally derived. A dose of 35 mg/kg Metrazol was required to produce a 50% convulsive response (CD50) in O'Grady mice and 50 mg/kg in the control parent strain. No differences in convulsive thresholds to Metrazol were obtained between untreated Swiss-Webster mice and mice of the same strain made audiosusceptible by RbCl intake or Mg deficiency.