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Microbial transformation of pyridine derivatives: alpha-picolinate metabolism by a gram-negative coccus

Shukla, O.P.; Kaul, S.M.; Khanna, M.

Indian Journal of Biochemistry and Biophysics 14(3): 292-295

1977

ISSN/ISBN: 0301-1208
PMID: 612544
Document Number: 4348
A Gram-negative coccus utilizing a:-picolinate and nicotinate as the sole source of carbon, nitrogen and energy has been isolated from soil; other pyridine derivath.es are not metabolised. 6-Hydroxypicolinate and 2,5-dihydroxypyridine have been isolated and characterized as transformation products of c-picolinate. These two compounds as well as maleamate are oxidised by a:-picolinate-grown cells. c-Picolinate hydroxylase, 2, 5-dihydroxypyridine oxidase and maleamic deamidase have been detected in cell-free extracts. a:-Picolinate is degraded by this organism via 6-hydroxypicolinate, 2,5-dihydroxypyridine and maleamate as intermediates.

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Microbial transformation of pyridine derivatives: alpha-picolinate metabolism by a gram-negative coccus

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