Microbial transformation of azacarbazoles. I. N-methylation of alpha-, beta-, and gamma-carbolines by Kitasatosporia setae strain
Peczyńska-Czoch, W.; Mordarski, M.; Kaczmarek, L.; Nantka-Namirski, P.
Archivum Immunologiae et Therapiae Experimentalis 35(2): 89-95
1987
ISSN/ISBN: 0004-069X PMID: 3447539 Document Number: 303423
Microbial transformation of selected azacarbazoles, compounds noted for their activity as antitumor agents, conducted with Kitasatosporia setae strain resulted in N-methylation of pyridine nucleus of alpha-, beta- and gamma-carboline molecule. Formed quaternized intermediates were converted in alkaline conditions into corresponding iso-carbolines. The structure of the final products, alpha-, beta- and gamma-iso-carbolines have been established on the basis of spectral data and confirmed by chemical synthesis.