Beta,gamma-methylene ATP but not alpha,beta-methylene ATP mimics the inhibitory effect of ATP on ventricular automaticity
Hernández, J.; Laorden, M.L.; Ruiz, F.; Ribeiro, J.A.
Pharmacology and Toxicology 86(2): 68-70
2000
ISSN/ISBN: 0901-9928 PMID: 10728917 Document Number: 516905
The effects of alpha,beta- and beta,gamma-methylene ATP on ventricular automaticity induced by local injury in the right ventricle of rats pretreated with reserpine, were investigated and compared with the effects of ATP and adenosine. beta,gamma-Methylene ATP but not alpha,beta-methylene ATP mimicked the inhibitory effect of both ATP and adenosine on the spontaneous automaticity. In low concentrations, adenosine was more effective than ATP. alpha,beta-Methylene ATP caused little or no effect on ventricular automaticity. The results suggest that the effect of ATP might depend on its hydrolysis into AMP/adenosine.