Top Abstract Purchase Related
Home
>
Node
>
Subnode

Microbial transformation of azacarbazoles. V. Studies on N-1 methylation of 4-methyl-alpha-carboline by Kitasatosporia setae strain

Peczyńska-Czoch, W.

Archivum Immunologiae et Therapiae Experimentalis 35(2): 117-124

1987

ISSN/ISBN: 0004-069X
PMID: 3447527
Document Number: 293889
N-1 methylation of an azacarbazole, 4-methyl-alpha-carboline by Kitasatosporia setae was associated with antifungal metabolite production. Incubation of 4-methyl-alpha-carboline with intact cells or homogenates of Kitasatosporia setae and L-/14CH3/-methionine or adenosyl-S-/14CH3/-L-methionine yielded radioactive products, 1,4-dimethyl-alpha-iso-carboline. The presence of 14C-labelled methyl groups in antifungal metabolite has been also observed. Mutants of Kitasatosporia setae with lost abilities to produce antifungal metabolite did not convert 4-methyl-alpha-carboline into its methyl derivative.

Document emailed within 1 workday
Secure & encrypted payments

Peczyńska-Czoch, W.; Mordarski, M.; Kaczmarek, L.; Nantka-Namirski, P. 1987: Microbial transformation of azacarbazoles. I. N-methylation of alpha-, beta-, and gamma-carbolines by Kitasatosporia setae strain Archivum Immunologiae et Therapiae Experimentalis 35(2): 89-95
Peczyńska-Czoch, W. 1987: Microbial transformation of azacarbazoles. VIII. Production of 14C-labelled benzo-alpha-iso-carbolines by permeabilized cells of Kitasatosporia setae strain Archivum Immunologiae et Therapiae Experimentalis 35(2): 139-142
Romanovich, A.I.; Chizhov, O.S.; Sviridov, A.F. 1988: Synthetic studies in the series of polyene macrolide antibiotics. 5. Synthesis of methyl-2,4,6-trideoxy-2,4-di-C-methyl-alpha-L- gluco-hexopyranoside and methyl-2,4,6-trideoxy-2,4-di-C-methyl- alpha-L-manno-hexopyranoside, the stereoisomers of the C33-C38 fragment of amphotericin B Bioorganicheskaia Khimiia 14(8): 1109-1112
Shimada, T.; Guengerich, F.P. 1991: Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes Cancer Research 51(19): 5284-5291
Shukla, O.P.; Kaul, S.M.; Khanna, M. 1977: Microbial transformation of pyridine derivatives: alpha-picolinate metabolism by a gram-negative coccus Indian Journal of Biochemistry and Biophysics 14(3): 292-295
Destro, F. 1959: Preliminary studies of the use of 6-alpha-methyl-alpha-acetoxyprogesterone (M.A.P.) and 17-alpha-acetoxyprogesterone (A.P.) in gynecological and obstetrical therapy Minerva Ginecologica 11(6): 263-268
Saikawa, I.; Takai, A.; Nakashima, Y.; Ikegami, T.; Hayakawa, H.; Takagi, T.; Yamauchi, H. 1980: Studies on the absorption distribution and excretion of 14C-labelled sodium 7-[D(-)-alpha-(4-ethyl-2,3-dioxo-1-piperazine-carboxamido)-alpha-(4-hydroxyphenyl l) acetamido]-3-[(1-methyl-1H-tetrazol-5-yl) thiomethyl]-3-cephem-4-carboxylate (14C-cefoperazone) in rats and mice Japanese Journal of Antibiotics 33(10): 1084-1096
Prado de Carvalho, L.; Venault, P.; Cavalheiro, E.; Kaijima, M.; Valin, A.; Dodd, R.H.; Potier, P.; Rossier, J.; Chapouthier, G. 1983: Distinct behavioral and pharmacological effects of two benzodiazepine antagonists: Ro 15-1788 and methyl beta-carboline Advances in Biochemical Psychopharmacology 38: 175-187
Takeda, M.; Takagi, T. 1980: Effects of a new bronchodilator, (alpha RS)-3-formamido-4-hydroxy-alpha-[[[(alpha RS)-p-methoxy-alpha-methylphenethyl] amino] methyl] benzyl alcohol fumarate dihydrate (BD 40A) on gastric acid secretion and gastrointestinal motility Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 76(3): 185-191
During, R.; Mauck, I.; Schwarzlos, G. 1977: Blood coagulation studies of therapeutic abortion induced by 15-methyl-prostaglandin F2 alpha Zentralblatt für Gynakologie 99(22): 1361-1365
Yang, X.M.; Luo, Z.P.; Zhou, J.H. 1989: Behavioral evidence for the role of noradrenaline in the putative anxiogenic actions of the inverse benzodiazepine receptor agonist methyl-4-ethyl-6,7-dimethoxy-beta-carboline-3-carboxylate Journal of Pharmacology and Experimental Therapeutics 250(1): 358-363
Colasanti, B.K.; Trotter, R.R. 1977: Enhanced ocular penetration of the methyl ester of (+/-) alpha-methyl-para-tyrosine after lontophoresis Archives Internationales de Pharmacodynamie et de Therapie 228(1): 171-176
Wang, Y.F.; Jin, Y.C.; Wu, Y.E.; Gu, L.J.; Xie, X.H. 1989: The cervix-ripening effect of 15-methyl-prostaglandin F2 alpha methyl ester before vacuum aspiration for termination of early pregnancy in primigravidae Chinese Medical Journal 102(3): 200-202
Galegov, G.A.; Vladyko, A.S.; Linitskaia, G.L.; Shobukhov, V.M. 1981: Effect of amantadine (1-aminoadamantane) and remantadine (alpha-methyl-1-adamantane methyl amine) hydrochlorides on formation of influenza a viral proteins Voprosy Meditsinskoi Khimii 27(2): 251-254
Romanovich, A.Iu.; Chizhov, O.S.; Sviridov, A.F. 1988: Synthetic studies in the series of polyene macrolide antibiotics. 6. Synthesis of methyl-2,4,6-trideoxy-2,4-dimethyl-alpha-altro- hexopyranoside, the C33-C38 fragment of amphotericin B Bioorganicheskaia Khimiia 14(8): 1113-1116
Cox, R.; Irving, C.C. 1977: Inhibition of DNA methylation by S-adenosylethionine with the production of methyl-deficient DNA in regenerating rat liver Cancer Research 37(1): 222-225
Kubo, S.; Uesaka, I.; Matsubara, I.; Ishihara, T.; Kasé, Y. 1977: Pharmacological studies of o-chloro-alpha-[(tert.-butylamino)methyl]benzylalcohol hydrochloride (C-78), a new bronchodilator. II. Actions on the cardio-vascular system and smooth muscle organs Arzneimittel-Forschung 27(7): 1433-1439
Arutiunian, E.E.; Gonchar, N.A.; Levchenko, I.I.; Gruber, I.M.; Nikol'skaia, I.I. 1991: Isoelectric focusing of methylation and restriction enzymes from Staphylococcus aureus strain 6782 Biokhimiia 56(2): 281-288
Nantka-Namirski, P.; Zieleniak, J. 1977: Carboline synthesis by the Graebe-Ullmann method. V. Synthesis and transformations of gamma-carboline N-oxide Acta Poloniae Pharmaceutica 34(5): 455-458
Marmo, E.; Somma, A.; Ottavo, R.; Vairo, G.; Spaziante, G.; DiMezza, F.; Paone, G. 1981: Effects of prostacyclin, 6-keto-PGF1 alpha PGF2 alpha and 15[S]15-methyl-PGF2 alpha on platelet aggregation in vitro Journal of Medicine 12(2-3): 97-108