Suppression of influenza virus NP-protein mRNA translation in vitro with derivatives of an antisense oligonucleotide
Abramova, T.V.; Vlasov, V.V.; Ivanova, E.M.; Zarytova, V.F.; Fokina, T.N.; Frolova, E.I.; Iurchenko, L.V.
Molekuliarnaia Biologiia 28(2): 307-312
1994
ISSN/ISBN: 0026-8984 PMID: 8183262 Document Number: 434681
Inhibition of the influenza virus protein NP mRNA with derivatives of an antisense oligonucleotide complementary to the 5' terminus of the mRNA was investigated. The derivatives were prepared by conjugation of aromatic 2-chloroethylamine, cholesterol, porphyrin, and phenazine groups to the 5'-terminal phosphate of the oligonucleotide. The most efficient inhibitors were found to be the conjugates bearing the alkylating, cholesterol and phenaznium groups.