Influence of various tRNA conformers on mRNA translation in cell-free protein-synthesizing systems
Negrutskiĭ, B.S.; El'skaia, A.V.
Ukrainskii Biokhimicheskii Zhurnal 61(3): 58-62
1989
ISSN/ISBN: 0201-8470 PMID: 2749914 Document Number: 338163
It is found that both globin mRNA translation in the wheat germ system and reticulocyte lysate protein synthesis are inhibited by the excess of exogenous tRNA. The inhibition was more expressed in the presence of inactive tRNA conformers. The data obtained confirm the possibility in principle of inactive tRNA conformers participation in negative regulation of protein synthesis.
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