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Determination of the species specificity of interferons in the translation of the their mRNA from various cell cultures

Nosik, D.N.; Novokhatskiĭ, A.S.; Liakh, L.A.; Khil'ko, S.N.; Aspetov, R.D.

Antibiotiki 28(1): 27-31

1983

ISSN/ISBN: 0003-5637
PMID: 6187280
Document Number: 212079
Interferons obtained on induction of human lymphocytes with Newcastle viruses and staphylococcal enterotoxin A and diploid fibroblast cells of human embryos with poly (I).poly (C), as well as translation products of interferon mRNA obtained from these cells were analysed serologically. It was shown that the main type of interferon produced by the cells depended on the cell culture and inductor nature. It was defined at the level of the respective gene depression. Effective translation of mRNA of the interferons of the 3 types makes possible production of cDNA and creation of bacterial plasmids coding the genetic information for the synthesis of human interferon.

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