Inhibitory effects of esculentoside A on mouse macrophages and antibody production
Ju, D.W.; Zheng, Q.Y.; Wang, H.B.; Guan, X.J.; Fang, J.; Yi, Y.H.
Yao Xue Xue Bao 29(4): 252-255
1994
ISSN/ISBN: 0513-4870 PMID: 7976339 Document Number: 434151
Esculentoside A (EsA) is a kind of saponin isolated from Phytolacca esculenta Van Houtte. It was shown to significantly inhibit phagocytic activity, intracellular and extracellular production of interleukin-1 by thioglycollate primed murine peritoneal macrophages in vitro at the concentration 0.01 apprx 1.0 mu-mol . L-1. In vivo experiments showed that EsA 2. 5 apprx 5 mg . kg-1 markedly decreased serum hemolysin concentration in sensitized mice challenged with sheep red blood cells. Inhibition of antibody production by B lymphocytes, phagocytosis and the production of inflammatory mediators by macrophages may partially explain the wide and strong anti-inflammatory effect of EsA.