Comparison of pharmacological effects of L- and DL-n-butyl-scopolamine in rat uterus
Liao, W.J.; Qu, Z.W.; Zhang, J.T.
Yao Xue Xue Bao 29(1): 24-27
1994
ISSN/ISBN: 0513-4870 PMID: 8036897 Document Number: 434150
The affinities of L-n-butyl-scopolamine, DL-n-butyl-scopolamine and atropine for the M-cholinergic receptors of rat uterus were compared using radioligand binding assay. Results showed that the affinity of L-n-butyl-scopolamine for the M-receptors was similar to that of DL-n-butyl-scopolamine, but lower than that of atropine. In isolated rat uterus, L- and DL-n-butyl-scopolamine were found not to influence the automatic contraction but antagonize the contraction induced by acetylcholine with nearly the same PA-2, although the PA-2 of both compounds were still lower than that of atropine. Therefore, no difference between L- and DL-n-butyl-scopolamine in either biological activity or receptor affinity was observed.