A study on the inhibitory effects of several chemicals on the production of nitrogen oxide in alveolar macrophage induced by asbestos
Fan, J.; Wang, Q.; Wu, W.
Zhonghua Yu Fang Yi Xue Za Zhi 31(1): 31-33
1997
ISSN/ISBN: 0253-9624 PMID: 9812634 Document Number: 483863
Induction of chrysotile produced in Mang ai to the production of nitrogen oxide (NO) and effects of mixed rare earths (MRE), sodium selenite (SS) and aluminium citrate on the production of NO in alveolar macrophage (AM) induced by asbestos fiber were observed by in vitro cell culture technique and determination of nitrite ion content in the culture medium. Results showed that chrysotile fiber could increase nitrite ion content in the culture medium, with an obvious dose-dependent relationship. MRE, selenite, and aluminium citrate all could inhibit the production of NO in AM induced by asbestos, and its inhibitiory effects increased with the concentration of the above-mentioned chemicals. It suggests antagonism of MRE and selenite to pathogenicity of asbestos may be used in practice.