Effects of aztreonam and netilmicin upon alveolar macrophage function
Valerio, G.; Grasso, R.; Lella, A.; Pirelli, E.; Musci, C.; Carnimeo, N.
Chemioterapia International Journal of the Mediterranean Society of ChemoTherapy 5(2): 109-112
1986
ISSN/ISBN: 0392-906X PMID: 3708716 Document Number: 281031
Both aztreonam and netilmicin showed no toxic effect on alveolar macrophage function when administered at varying concentrations. Killing ability was unchanged as well. The increase of enzyme delivery, assessed at varying concentrations, was very limited and of no relevance in the pathogenesis of possible tissue damage. It can be explained on the basis of a change in the permeability of membranes or to output during phagocytosis. In cultures containing either antibiotic under similar conditions we did not note any substantial differences. The concentrations tested can be used safely in the therapy of infections due to most gram-negative bacteria.