Relationship between effect of sodium selenite on blocking mesothelioma induced by crocidolite and level of serum lipid peroxidation in rats
Yang, J.; Luo, S.; Liu, X.
Hua Xi Yi Ke Da Xue Xue Bao 25(1): 66-69
1994
ISSN/ISBN: 0257-7712 PMID: 8070777 Document Number: 425987
This paper reports the relationship between the effect of sodium selenite on blocking mesothelioma induced by crocidolite and the level of serum lipid peroxidation in rats. The result showed that sodium selenite solution (5ppm) might not only block and slow down the formation and growth of mesothelioma but also prevent peroxidation produced by crocidolite. The incidence of mesothelioma and the content of LPO in the Se group were lower than those in the positive control group in different periods (0-430 days and 0-530 days respectively). The survival time (341 days) of the first case of mesothelioma and the death peak period (530-630 days) in the Se group were longer than those (237 days and 430-530 days respectively) in the positive group. There was a good correlation between the change of G value in the Se group and the change of G value in the positive control group in different experimental periods (r = 0.9991). These results will provide scientific bases for recognizing the mechanism of mesothelioma and for furthering the practice in the people exposed to asbestos.