Top Abstract Purchase Related
Home
>
Node
>
Subnode

New strategies for oligonucleotide synthesis by use of 2-trimethylsilylethyl and 2-trimethylsilylethoxymethyl as the phosphate and 2'-hydroxyl protecting groups, respectively

Wada, T.; Tobe, M.; Nagayama, T.; Furusawa, K.; Sekine, M.

Nucleic Acids Symposium Series 29: 9-10

1993

ISSN/ISBN: 0261-3166
PMID: 8247808
Document Number: 420855
The 2-Trimethylsilylethyl (TSE) group was found to be useful as a protecting group for the internucleotidic phosphate in DNA synthesis. Oligodeoxyribonucleotides were synthesized in good yields by using phosphoramidite building blocks having the TSE group. In RNA synthesis, 2-trimethylsilylethoxymethyl (SEM) group was introduced as a new protecting group for the 2'-hydroxyl. Selective protection of this function with SEM-Cl was achieved in good yield by use of 3',5'-O-bis(tert-butyl)silanediyl ribonucleoside derivatives.

Document emailed within 1 workday
Secure & encrypted payments

Braun, K.; Kuhl, P. 2002: Are PhAcOZ and Nsc suitable N alpha-protecting groups for protease-catalysed peptide synthesis? Die Pharmazie 57(5): 310-312
Zilmer, M.K.; Tarve, U.S. 1975: Isolation of active preparation of Na+, K+-ATPase from cattle brain and study of the role of carboxyl, sulfhydryl and hydroxyl groups Ukrains'kyi Biokhimichnyi Zhurnal 47(4): 458-464
Fedorin, G.F.; Georgievs'kiĭ, V.P. 1973: Chromatographic separation of coumarins containing hydroxyl groups in the ring and side-chain on a thin-layer of aluminium oxide Farmatsevtychnyi Zhurnal 4: 41-44
Xu, P.; Yang, Y.; Shi, Y.; Lei, P-Sheng.; Liu, L. 2007: Synthesis of derivatives of (9S) -9-hydroxyl-12-methylene erythromycin A and their antibacterial activity in vitro Yao Xue Xue Bao 42(5): 497-501
Zhang, J.; Chen, Z.; Zhang, W.; Guan, L.; Zhang, M.; Qui, J.; Yuan, N.; Cheng, L. 1998: Study of a new type of material substituted for human hard tissues-hydroxyl poly calcium sodium phosphate: histologic report implants in mandible of animals Hua Xi Yi Ke da Xue Xue Bao 29(2): 143-146
Dubey IYa; Lyapina, T.V.; Fedoryak, D.M. 1991: H-phosphonate oligonucleotide synthesis in solution Nucleic Acids Symposium Series 24: 270
Reese, C.B.; Song, Q. 1997: A new approach to oligonucleotide synthesis in solution Nucleic Acids Symposium Series 37: 1-2
Bell, J.; Condren, M. 2016: Communication Strategies for Empowering and Protecting Children Journal of Pediatric Pharmacology and Therapeutics: Jppt: the Official Journal of Ppag 21(2): 176-184
Kitamura, M.; Nimura, A.; Kunimoto, K.; Segawa, H.; Shimidzu, T. 1991: Synthesis and properties of oligonucleotide derivative with P(V) porphyrin Nucleic Acids Symposium Series 25: 13-14
Kamaike, K.; Yamakage, S.; Hasegawa, Y.; Ishido, Y. 1986: Oligonucleotide synthesis on a cellulose acetate functionalized with a spacer Nucleic Acids Symposium Series 17: 89-92
Vu, H.; McCollum, C.; Lotys, C.; Andrus, A. 1990: New reagents and solid support for automated oligonucleotide synthesis Nucleic Acids Symposium Series 22: 63-64
Romano, G.; Claudio, P.P.; Kaiser, H.E.; Giordano, A. 1998: Recent advances, prospects and problems in designing new strategies for oligonucleotide and gene delivery in therapy In Vivo 12(1): 59-67
Beher, W.T.; Lin, G.J. 1975: Specificity of oxidation of bile-salt hydroxyl groups by crude extracts of Pseudomonas testosteroni (ATCC 11996) used in determining bile salts Clinical Chemistry 21(11): 1630-1631
Leonard, W.R. 1991: Household-level strategies for protecting children from seasonal food scarcity Social Science and Medicine 33(10): 1127-1133
Takaku, H.; Yoshida, M.; Hata, T. 1979: 8-Quinolinesulphonyltetrazolide (QStet) as a new coupling agent for oligonucleotide synthesis via phosphotriester approach Nucleic Acids Symposium Series 6: S181-S182
Denisova, L.I.; Zagrebel'nyĭ, S.N.; Pustoshilova, N.M. 1980: Reiterative poly(A) synthesis on oligonucleotide templates in an Escherichia coli RNA-polymerase system Molekuliarnaia Biologiia 14(6): 1372-1377
Pontén, I.; Kim, S.K.; Gräslund, A.; Nordén, B.; Jernström, B. 1994: Synthesis and characterization of a (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide-oligonucleotide adduct Iarc Scientific Publications 1994(125): 433-436
Pare, M 2003: Why have street children disappeared? The role of international human rights law in protecting vulnerable groups International Journal of Children's Rights 11(1): 1-32
Andrus, A.; Wright, P.; Wang, J.; Mullah, B.; Baier, J.; Mason, J.; Kaufman, G. 1995: Synthesis and purification in a single column on a high-throughput automated oligonucleotide production system Nucleic Acids Symposium Series 34: 183-184
Wolski, T. 1978: The choice of medium suitable for the reaction of thiol groups with halogen derivatives in the synthesis of some purine and pyrimidine compounds. I. Synthesis of azathioprine Polish Journal of Pharmacology and Pharmacy 30(4): 593-599