Metabolism and catabolism to CO2 of [14C] gamma-aminobutyric acid conjugates with pyridoxal phosphate, nicotinate and biotin
Rozanov, A.I.; Tishchenko, D.V.; Zaporozhchenko, A.V.
Ukrainskii Biokhimicheskii Zhurnal 65(4): 87-94
1993
ISSN/ISBN: 0201-8470 PMID: 8284828 Document Number: 420856
Pharmacokinetics and catabolism to CO2 in the mice organism and metabolic transformation by the tissues homogenates of [1-14C] GABA and its conjugates with nicotinate, pyridoxal phosphate and biotin have been studied. The permeability of nicotinoyl-GABA through the hemato-encephalic barrier was 10 times as much as the corresponding value for GABA and its conjugates with other vitamins. PLP-GABA is eliminated more rapidly from the brain in comparison with GABA, biotinyl-GABA is retained to a higher degree in kidneys, the entero-hepatic recycling takes place more actively for nicotinoyl-GABA. The latter, in contrast to biotinyl-GABA, remains unaffected by the liver, intestine mucose membrane and brain proteases and is catabolized to CO2 to a considerably lower extent as compared with GABA, perhaps due to the intestine bacterial microflora.