Cerebrospinal fluid gamma-aminobutyric acid and homovanillic acid in depressive disorders
Kasa, K.; Otsuki, S.; Yamamoto, M.; Sato, M.; Kuroda, H.; Ogawa, N.
Biological Psychiatry 17(8): 877-883
1982
ISSN/ISBN: 0006-3223 PMID: 7115838 Document Number: 188463
gamma-Aminobutyric acid (GABA) and homovanillic acid (HVA) levels were determined in the lumbar cerebrospinal fluid (CSF) of hospitalized patients suffering from depression and in a control group. Both mean CSF GABA and HVA levels in the patients with depression were significantly lower than those of the control group (p less than 0.05, p less than 0.01, respectively). No positive correlation was found between the changes in CSF GABA and HVA levels in the patients with depression. The Hamilton Rating score in these depressed patients, age, and sex showed no correlation to CSF GABA levels. It is suggested that decreased activity in the central GABAergic and dopaminergic system may be involved in the pathogenesis of depression.