Effect of psychotropic substances and gamma-aminobutyric acid analogs and derivatives on the release of 3H-D-aspartic acid from perfused synaptosomes of the rat cerebral cortex
Prikhozhan, A.V.; Kovalev, G.I.; Raevskiĭ, K.S.
Farmakologiia i Toksikologiia 50(1): 10-14
1987
ISSN/ISBN: 0014-8318 PMID: 3556541 Document Number: 292467
It was shown in experiments in vitro that neuroleptics haloperidol and sulpiride, antidepressants desipramine and amitriptyline, nootropic agent piracetam, benzodiazepine tranquillizer phenazepam, psychostimulant phenamine and agonist of GABA A-receptors tetrahydroisoxazolopyridinol depending on the concentration in the micromolar range decrease K+-stimulated release of 3H-D-aspartic acid from rat brain cortex synaptosomes. Agonists of GABA B-receptors phenibut and baclofen as well as valproate and sodium oxybutyrate failed to exert a noticeable effect on the process under study.