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Comparative analysis of action of beta-phenyl derivatives of glutamic and gamma-aminobutyric acid on cerebral blood flow and cerebrovascular endothelium after irreversible occlusion of the common carotid artery

Volotova, E.V.; Kurkin, D.V.; Mazina, N.V.; Berestovitskaia, V.M.; Vasil'eva, O.S.

Eksperimental'naia i Klinicheskaia Farmakologiia 76(6): 11-13

2013

ISSN/ISBN: 0869-2092
PMID: 24003482
Document Number: 668215
A comparative analysis of the effect of phenyl derivatives of glutamic (RGPU-135) and gamma-aminobutyric acid (Phenibut) on cerebral blood flow, vasodilatory endothelial function and the number of circulating endothelial cells desquamated in animals after irreversible occlusion of the common carotid arteries. It was found that animals treated prophylactically by RGPU-135, after occlusion of the common carotid arteries have higher cerebral blood flow and lower the severity of endothelial dysfunction than in animals treated with Phenibut.

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