Effect of structural analogs of gamma-aminobutyric acid on serotonin- and dopaminergic mechanisms

Nurmand, L.B.; Otter, M.I.; Vasar, E.E.; Nurmand, L.B; Otter, M.I; Vasar, E.E

Home

>

Node

>

Subnode

Effect of structural analogs of gamma-aminobutyric acid on serotonin- and dopaminergic mechanisms

Nurmand, L.B.; Otter, M.I.; Vasar, E.E.

Farmakologiia i Toksikologiia 43(3): 288-291

1980

ISSN/ISBN: 0014-8318

PMID: 7449968

Document Number: 161925

The behavioral and biochemical effects of some GABA analogues (fenibut, fepiron and sodium hydroxybutyrate) were studied in 400 male albino mice. It was shown that although these compounds exert similar behavioral effects, their effects on brain monoamine metabolism are different. Fenibut largely stimulates the serotoninergic, fepiron inhibits the dopaminergic, while sodium hydroxybutyrate affects both the monoaminergic processes.