Evaluation of clinical efficacy of sulbenicillin following surgery of malignant maxillary tumors. Transport of sulbenicillin to the exudates from the surgical wound of the maxilla and its therapeutic effects
Hakamata, M.; Hozawa, J.; Saito, H.; Fukuoka, K.; Yamagami, M.; Usami, S.
Japanese Journal of Antibiotics 35(5): 1254-1260
1982
ISSN/ISBN: 0368-2781 PMID: 7131758 Document Number: 188464
In order to know the amount of sulbenicillin (SB-PC) transported to the maxillary sinus through the blood supply after injecting by intravenous drip infusion, the authors measured SB-PC content of the exudate which was gathered from the exploratory operative maxillary sinus. This measurement was performed 3 times at 2, 4 and 6 hours after injecting 5 g of SB-PC by intravenous drip infusion. From results of these measurements, it became obvious that the SB-PC content reached to the maximum value (24.5 +/- 16.69 mcg/ml) at 2--4 hours after the injection. Next, the preventive and therapeutic effect on the postoperative maxillary infection was evaluated for 13 patients of maxillary cancer. The effect was excellent in 2 cases (16.7%), good in 8 cases (66.7%) and fair in 2 cases (16.7%). So, the ratio of effectiveness was 83.3%. The side effect of SB-PC was observed only in 1 patient who complained of palpitation, but it was not severe.