Depletion, accumulation and excretion of trace elements during total parenteral nutrition
Yamato, H.
Tokushima Journal of Experimental Medicine 29(1-2): 21-37
1982
ISSN/ISBN: 0040-8875 PMID: 6815828 Document Number: 188465
The concentrations of Zn, Cu and Mn in the serum and organs of rats and the excretions of these trace elements (TE) were measured during total parenteral nutrition (TPN) with solutions containing various concentrations of TE. From the concentrations of TE in various organs, the daily requirements of TE during TPN were estimated and indicators of depletion or accumulation of TE were evaluated. When there was no loss of gastrointestinal (GI) fluid, the tissue TE concentrations could be maintained within normal ranges by administration of Zn at 80 .mu.g/kg per day, Cu at 12 .mu.g/kg per day and Mn at 9 .mu.g/kg per day. When there was abnormal loss of bile and pancreatic juice, daily doses of 180 .mu.g/kg of Zn, 25 .mu.g/kg of Cu and 16 .mu.g/kg of Mn were necessary to maintain positive balances of the respective TE. When deficiency of Zn or Cu occurred, determination of the Zn or Cu concentration of the serum and the urinary excretions of these elements gave useful information. When overdoses of TE were administered, determinations of their excretions were more valuable than determinations of their serum concentrations. The Zn, Cu and Mn concentrations in the bile were especially useful in determining suitable doses of TE.