In vitro interaction between clindamycin and trimethoprim in combination on staphylococci
El-Baz, W.; Abd-el Hamid, T.; Tantawi, A.; Sabbour, M.S.
International Journal of Clinical Pharmacology Research 13(3): 187-192
1993
ISSN/ISBN: 0251-1649 PMID: 8225702 Document Number: 415761
The in-vitro interaction between clindamycin and trimethoprim was tested on 10 staphylococcal clinical isolates by the checkerboard technique and by the time-kill curve. Indifference was demonstrated against seven of these strains and antagonism against three. The clindamycin/trimethoprim combination is of no value if the purpose of the combination is to obtain synergy against staphylococci. However, the combination is useful against mild polymicrobial infections due to Gram-positive aerobes, anaerobes and Enterobacteriaceae.