An absence of interaction of sulfametrol-trimethoprim with insulin or sulphonylurea derivatives in diabetics
Kaspar, L.
Wiener Klinische Wochenschrift 92(8): 276-279
1980
ISSN/ISBN: 0043-5325 PMID: 6996341 Document Number: 161679
Since diabetics frequently suffer from urinary tract infections which can be successfully treated with a combination of sulphonamide derivatives and the bacteriocide trimethoprim, the question of possible interactions between such agents and diabetic therapy is of interest. A double-blind crossover trial was, therefore, carried out in 10 diabetics who were being treated with insulin, and 10 who were under treatment with sulphonylurea derivatives. Sulfametrol was administered in combination with trimethoprim (= Lidaprim). The blood glucose level was determined 3 times daily. No tendency towards hypoglycaemia was observed under treatment with the active agent in either group of patients. Within 5 days creatinine and blood urea nitrogen had increased to pathological levels in those patients who showed previous renal damage. It is concluded that the lack of interaction of these drugs with diabetes therapy justifies the use of these chemotherapeutic agents in diabetics. They are effective and relatively inexpensive in comparison with other agents. Subjective tolerance is also good.