Causes of insulin secretion disorders in non-insulin dependent diabetics. Comparison of in vivo results with examinations of isolated islet cells
Lohmann, D.; Jahr, H.; Verlohren, H.J.; Zühlke, H.
Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 36(2): 47-51
1981
ISSN/ISBN: 0044-2542 PMID: 7013297 Document Number: 173197
Non-insulin dependent diabetics (NIDD) used in our experiments do not or in a small extend only respond to glucose; but glucagon and tolbutamide loads result in an increased insulin secretion. In contrast, pancreatic islets isolated from biopsies of the pancreas do not show any differences in insulin secretion, biosynthesis and content between NIDD and control groups. Some reasons of these differences between in vivo and in vitro results are discussed.