Synthesis of 11-aryl-7,8,9,10-tetrahydro-1,2,3-triazino- (4',5':4,5) -thienol- - (2,3-b) -quinolines with antianaphylactic action
Wagner, G.; Vieweg, H.; Leistner, S.
Die Pharmazie 48(8): 576-578
1993
ISSN/ISBN: 0031-7144 PMID: 8415856 Document Number: 413216
Title compounds of structure B with an oxo function in position 4 of the triazine ring were synthesized by reaction of the aminocarboxamides A with sodium nitrite in acetic acid. Aminocarbonitriles of structure H yielded with sodium nitrite in acetic acid and hydrochloric acid the 4-chloro derivatives I. These compounds gave with N-nucleophiles, methoxide or thiourea the substances J. Tetracyclic compounds with a hydroxyethyl or a piperidinoethyl residue in position 3 in the triazine ring (E, G) were also prepared. Some of the investigated compounds showed an antianaphylactic activity.