The effect of hypothermia and dalargin on lipid peroxidation in rat tissues
L'vova, S.P.; Gorbunova, T.F.; Abaeva, E.M.
Voprosy Meditsinskoi Khimii 39(3): 21-24
1993
ISSN/ISBN: 0042-8809 PMID: 8333182 Document Number: 412394
The rate of lipid peroxidation was studied in rat brain, liver, skeletal muscles and myocardial tissues in dynamics of hypothermia. Cooling of the animals down to 30 degrees induced lipid peroxidation, which was markedly expressed within 3-hour continuation of the treatment. Profound hypothermia (20 degrees) increased levels of malonic dialdehyde in the tissues studied by 30-160%, while prolongation of the impairment up to 3 hrs resulted in normalization of the lipid peroxidation parameters studied. The artificial hexapeptide dalargin, similar to leu-enkephalin, inhibited the rate of lipid peroxidation in profound hypothermia both in vivo and in vitro.