Status of the lipid peroxidation system in the tissues of rats following a 7-day flight on the Kosmos-1667 biosatellite
Delenyan, N.V.; Markin, A.A.
Kosmicheskaia Biologiia i Aviakosmicheskaia Meditsina 23(4): 34-37
1989
ISSN/ISBN: 0321-5040 PMID: 2586059 Document Number: 327236
Rats flown for 7 days on Cosmos-1667 were for the first time used to measure antioxidative enzymes (superoxid dismustase, glutathione peroxidase, glutathione reductase, catalase), lipid peroxidation products (diene conjugates, malonic dialdehyde, Schniff bases) and tocopherol. Enhanced lipid peroxidation in the heart was completely compensated by activation of antioxidative enzymes. The content of all lipid peroxidation products measured in the liver increased; this was accopanied by a decrease of glutathione peroxidase and an increase of superoxide dismutase activities. It is suggested that lipid peroxidation was activated in response to altered gravity.