Synthesis of 9,10-anthraquinone monoalkylaminoalkylhydrazones as potential antitumor drugs
Antonini, I.; Polucci, P.; Cola, D.; Palmieri, G.; Martelli, S.; Bontemps-Gracz, M.
Farmaco 48(12): 1641-1648
1993
ISSN/ISBN: 0014-827X PMID: 8135988 Document Number: 411659
In the constant search for new compounds endowed with antitumor activity we have synthesized a series of anthraquinone hydrazones, which can be seen either as opened-cycle modified anthrapyrazoles or as chromophore-modified anthracenediones. Seven 9,10-anthraquinone monoalkylaminoalkylhydra-zones (3c-i) were synthesized from 10,10-dibromoanthrone (4) and a suitable N-alkylhydrazine. The hydrazones were converted into hydrochlorides and tested for their cytotoxic activity against L1210 murine leukemia cells. Two of them possess marginal activity in vitro.