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Lipoperoxidative damage in experimental rabbits with atherosclerosis

Chen, Y.; Zhou, M.; Kong, H.

Chinese Medical Journal 106(2): 110-114

1993

ISSN/ISBN: 0366-6999
PMID: 8504693
Document Number: 410172
The extent of lipoperoxidation in experimental rabbits with atherosclerosis was determined dynamically during the experimental period of 65 days. Lipoperoxide (LPO) levels and selenium-dependent glutathions peroxidase (SeGSHPx) activities in liver, aorta, heart muscle, plasma erythrocyte (RBC) and platelet were examined on the 65th day. The results showed that the potential anti-lipoperoxidation in the atherosclerotic rabbits was decreased significantly, and the tissues were suffered from lipoperoxidative damage. It seems that there is a close relationship between lipoperoxidative damage and the development of atherosclerosis.

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