Nature of the lipoprotein antigen responsible for the development of resistance to experimental atherosclerosis following its use in immunization of newborn rabbits
Klimov, A.N.; Loviagina, T.N.; Nagornev, V.A.; Zubzhitskiĭ, I.N.; Petrova-Maslakova, L.G.
Voprosy Meditsinskoi Khimii 24(1): 131-136
1978
ISSN/ISBN: 0042-8809 PMID: 208295 Document Number: 132071
In order to develop a tolerance to experimental atherosclerosis newborn rabbits were immunized with various fractions of atherogenic lipoproteins (lipoproteins of low density, lipoproteins of very low density and total fraction of these lipoproteins), isolated from blood serum of adult rabbits with experimental hypercholesterolemia. The tolerance to atherosclerosis proved to be achieved in immunization with lipoproteins of very low density. The lesser effect was observed using the total fraction of lipoproteins. The tolerance was not developed in immunization with lipoproteins of low density.