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Inhibition of pyruvate kinase of bovine adrenal cortex by ATP: the role of magnesium

Vinogradov, V.V.; Iarotskiĭ, I.V.; Zavodnik, I.B.

Biokhimiia 57(1): 91-96

1992

ISSN/ISBN: 0320-9725
PMID: 1391208
Document Number: 404057
The effect of ATP on bovine adrenal cortex pyruvate kinase has been studied. ATP is a competitive inhibitor of the enzyme, the Ki being 3.2 mM. Based on the efficiency of tryptophan fluorescence quenching, it was concluded that the magnesium complex of ATP is a true enzyme inhibitor. The role of Mg2+ in the inhibition process consists in the formation of a bridge between the enzyme and ATP. The ATP-dependent mechanism of pyruvate kinase inhibition is a potential physiological regulator of the enzyme determining the lower threshold of its sensitivity in vivo.

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