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Isolation and evaluation of the structure of the new anthracycline antibiotics rubomycins F and H

Fomicheva, E.V.; Fedorova, G.B.; Potapova, N.P.; Katrukha, G.S.

Antibiotiki i Khimioterapiia 37(8): 27-29

1992

ISSN/ISBN: 0235-2990
PMID: 1456819
Document Number: 397529
The rubomycin complex produced by Streptomyces coeruleorubidus 4-157 was studied and the two novel anthracyclines i.e. rubomycins F and H were isolated. The study of the physicochemical properties of the novel antibiotics in comparison with rubomycin C (daunomycin) and the specially prepared 3'-N-carbmethoxyrubomycin C showed that rubomycin F was 3'-N-carbethoxydaunomycin and rubomycin H was 3'-N-carbmethoxydaunomycin. Therefore, rubomycins F and H are novel representatives of natural anthracyclines undescribed previously.

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