Antitumor antibiotics of the anthracycline series and their semisynthetic derivatives
Povarov, L.S.
Antibiotiki 22(7): 653-667
1977
ISSN/ISBN: 0003-5637 PMID: 883809 Document Number: 112244
In addition to their valuable qualities, antineoplastic anthracycline antibiotics have a number of drawbacks, high cardiotoxicity being the most significant. Many studies on the synthesis of anthracyclines and chemical modifications of natural antibiotics to produce derivatives with better therapeutic properties have been done. Such research and its results is reviewed and discussed, including in vitro and in vivo studies on tumors of humans and experimental animals (e.g., rats, mice, dogs).
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